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ea0048o2 | Oral Communications | SFEEU2017

Metastatic pituitary carcinoma in an SDHB mutation positive patient

Tufton Nicola , Roncaroli Federico , Hadjudemetriou Irene , Dang Mary N , Denes Judit , Guasti Leonardo , Thom Maria , Powell Michael , Baldeweg Stephanie E , Fersht Naomi , Korbonits Marta

Case history: A 63-year-old female presented with bi-temporal hemianopia. Pituitary MRI demonstrated a macroadenoma with suprasellar extension. Her medical history included a glomus tumour of the right ear treated with external beam radiotherapy (EBRT) 25 years previously. She had no evidence of pituitary hormone abnormality and had normal urinary metanephrines levels. She underwent transsphenoidal surgery with total resection and full recovery of her visual fields. Immunohist...

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ea0031oc5.8 | Pituitary and neoplasia | SFEBES2013

Pituitary adenoma and phaeochromocytoma/paraganglioma – a novel syndrome with a heterogeneous genetic background

Denes Judit , Swords Francesca , Rattenberry Eleanor , Xekouki Paraskevi , Kumar Ajith , Wassif Christopher , Fersht Naomi , Baldeweg Stephanie , Morris Damian , Lightman Stafford , Thompson Chris J , Agha Amar , Rees Aled , Druce Maralyn , Grieve Joan , Powell Michael , Boguszewski Cesar Luiz , Higham Claire , Davis Julian , Preda Cristina , Trouillas Jacqueline , Dalantaeva Nadezhda , Ribeiro-Oliveira Antonio , Dutta Pinaki , Roncaroli Federico , Thakker Rajesh V , Stevenson Mark , O'Sullivan Brendan , Taniere Phillipe , Skordilis Kassiani , Gabrovska Plamena , Barlier Anne , Ellard Sian , Stals Karen , Stratakis Constantine A. , Grossman Ashley B. , Maher Eamonn , Korbonits Marta

Pituitary adenomas and phaeochromocytoma/paragangliomas (PHAEO/PGL) can very rarely occur in the same patient or in the same family. Together, they are not known to be part of any classical endocrine neoplasia syndromes. In some caes the pathogenetic mechanism may be secondary to a PHAEO secreting GHRH leading to somatotroph hyperplasia and clinical acromegaly. However, we suggest several other mechanisms which could lead to the development of pituitary and PHAEO/PGL together:...

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Endocrine Abstracts

Metastatic pituitary carcinoma in an SDHB mutation positive patient

Pituitary adenoma and phaeochromocytoma/paraganglioma – a novel syndrome with a heterogeneous genetic background

BiosciAbstracts